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Research Overview

RESEARCH PROFILE:
DAYANJAN WIJESINGHE, PhD


School of Pharmacy | Bio

 

Research Profile: TRAUMA, CRITICAL CARE


Dayanjan S. Wijesinghe, PhD

Dayanjan S. Wijesinghe, PhD
Assistant Professor, VCU School of Pharmacy, Department of Pharmacotherapy & Outcomes Sciences
Assistant Director, VCU Lipidomics/Metabolomics Core Facility
Affiliate Faculty, VCU Department of Surgery, Division of Acute Care Surgical Services
Affiliate Faculty, VCU Department of Biochemistry

PUBLICATIONS:
View Dr. Wijesinghe's Publications via the National Library of Medicine's PubMed
Publications via Google Scholar/Publications

RESEARCH PROJECT 1:
The role of lipid mediators in the regulation of wound healing

RESEARCH PROJECT 2:
Identification of diagnostic and predictive biomarkers for use in guiding protocolized medical interventions


RESEARCH OVERVIEW

My primary interest in research is centered on the role played by bioactive lipids in the onset and resolution of inflammation. Inflammation is often referred to as the “silent killer” with strong links to negative outcome from a wide variety of disorders such as sepsis, cardiac arrest, trauma, hemorrhagic shock, myocardial infarctions, cancer Alzheimer’s disease, as well as arthritis and delayed wound healing. Due to the large diversity of lipids and the fact that closely related lipids often display different bioactivities, understanding the roles of lipids in these processes require the use of new and sophisticated tools with extreme analytical resolution. To this effect the most versatile tool in the qualitative and quantitative investigations of lipids to date is liquid chromatography coupled to atmospheric pressure ionization tandem mass spectrometry. To this end, an essential area of interest of research for me is the development of accurate qualitative and quantitative analytical platforms based on LC tandem mass spectrometry for the investigation of the lipid signaling processes.

Currently our group follow a workflow that utilize a combination of cutting edge LC and tandem mass spectrometry based untargeted and targeted analytical workflows to identify the role played by lipids and other small molecules in the onset and resolution of inflammation. The ultimate goal of our research group is to obtain a sufficient critical mass of knowledge with respect to the role played by these molecules in inflammatory disorders to enable successful pathway based medical interventions to be affected at subclinical stages of disease, thereby enabling proactive vs. reactive disease management.


CONTACT INFORMATION

VCU Lipidomics/Metabolomic Core Facility
Virginia Commonwealth University School of Medicine
PO Box 980614
1101 East Marshall Street
Lipidomic/Metabolomic Core Facility
Sanger Hall Room 2-006
Richmond, VA 23298-0614
USA

Phone:  804-484-0764
Office:   804-828-9678
Fax:       804-828-1473
Email:   wijesingheds@vcu.edu

Dr. Wijesinghe's Faculty Bio/School of Pharmacy

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  last updated: 12/02/2016




 

 

 
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